Two polymorphisms for the human hepatic lipase (HL) gene.
نویسندگان
چکیده
SOURCE AND DESCRIPTION OF CLONE: A 1.65 kb ECORI cDNA insert corresponding to the full length hepatic lipase (HL) sequence isolated from a rat liver cDNA library (I). CHROMOSOMAL LOCALIZATION: Chromosome 15q21 by somatic cell and in situ hybridization (2).
منابع مشابه
Functional characterization of 4 polymorphisms in promoter region of hepatic lipase gene.
Hepatic lipase (HL) is a lipolytic enzyme involved in the metabolism of plasma lipoproteins, especially high density lipoproteins. Association studies have provided strong evidence for relations of common mutations in the promoter region of the HL gene to postheparin plasma HL activity and the plasma high density lipoprotein cholesterol concentration, but the functional relevance of these polym...
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Immunoprecipitations of hepatic lipase from pulse-labeled rat liver have demonstrated that hepatic lipase is synthesized in two distinct molecular weight forms, HL-I (Mr = 51,000) and HL-II (Mr = 53,000). Both forms are immunologically related to purified hepatic lipase, but not to lipoprotein lipase. HL-I and HL-II are also kinetically related and represent different stages of intracellular pr...
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ورودعنوان ژورنال:
- Nucleic acids research
دوره 16 10 شماره
صفحات -
تاریخ انتشار 1988